On Desistence – The body of research on gender dysphoric youth indicates that many of these youths are no longer gender dysphoric upon reaching and progressing through puberty. It is possible that the youths that “desisted” either were not transgender in the first place or were pressured to disassociate from their transgender identity. Yet there are enough anecdotal accounts and extended studies regarding desisting youth to provide reasonable evidence that at least some, and likely a sizable fraction of individuals who express desires to be the gender opposite their natal sex or affirm that they are the opposite gender in childhood do not feel the same way at a later point in life.
On Determining Desistence – There is a lack of agreement between sources on whether gender dysphoric youth who will persist and desist can be differentiated from each other. On the whole, the evidence indicates there is a correlation between the strength of transgender expression (identifying as the other gender rather than simply expressing cross-gender behavior) and persistence, yet the correlation isn’t perfect. Some children who express a strong desire that they are the other gender desist, while some children with subthreshold gender dysphoria diagnoses persist through puberty.
On Social Transitioning – Social transitioning has positive mental health effects, but unknown effects on whether children will persist or desist. Social transitioning is put forward as one of the primary ways to support transgender children and is shown to reduce the rates of internalizing problems and anxiety among gender dysphoric youth. These children do still show elevated rates of anxiety. Additionally, some children who socially transition later do not feel gender dysphoric anymore and decide to not present as the opposite gender any longer. There is no evidence examining the rate at which individuals who socially transition retain their gender dysphoric feelings and transgender identities.
On Puberty Blockers – Puberty blockers, though reportedly safe, may have unintended medical consequences based on a review of studies. Studies show effects on bone growth and density. Yet other studies show positive mental health effects relative to transgender individuals who undergo puberty as their birth sex, as puberty is a time when living as a transgender individual can be particularly traumatic. It is unknown if placing individuals on puberty blockers affects the rate at which that population of individuals retains their gender dysphoria.